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THE ACTUAL CORONA MEDICINE ACCORDING TO LATEST ICMR GUIDELINES

THIRAVIYAM

Active Member
Senior Member
Joined
Sep 5, 2017
Messages
117
Points
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Recommendation for empiric use of hydroxy-chloroquine for prophylaxis of
SARS-CoV-2 infection

Background:
Hydroxy-chloroquine is found to be effective against coronavirus in laboratory studies and in-vivo
studies. Its use in prophylaxis is derived from available evidence of benefit as treatment and supported
by pre-clinical data. The following recommendation for the use of hydroxy-chloroquine as a prophylactic
agent against SARS-CoV-2 infection is based on these considerations, as well as risk-benefit
consideration, under exceptional circumstances that call for the protection of high-risk individuals.
The National Taskforce for COVID-19 recommends the use of hydroxy-chloroquine for
prophylaxis of SARS-CoV-2 infection for selected individuals as follows:

Eligible individuals:
• Asymptomatic healthcare workers involved in the care of suspected or confirmed cases of
COVID-19
• Asymptomatic household contacts of laboratory confirmed cases
Dose:
• Asymptomatic healthcare workers involved in the care of suspected or confirmed cases of
COVID-19: 400 mg twice a day on Day 1, followed by 400 mg once weekly for next 7 weeks; to
be taken with meals
• Asymptomatic household contacts of laboratory confirmed cases: 400 mg twice a day on Day 1,
followed by 400 mg once weekly for next 3 weeks; to be taken with meals

Exclusion/contraindications:
• The drug is not recommended for prophylaxis in children under 15 years of age.
• The drug is contraindicated in persons with known case of retinopathy, known hypersensitivity to
hydroxychloroquine, 4-aminoquinoline compounds

Key considerations:
• The drug has to be given only on the prescription of a registered medical practitioner.
• Advised to consult with a physician for any adverse event or potential drug interaction before
initiation of medication
• The prophylactic use of hydroxychloroquine to be coupled with the pharmacovigilance for
adverse drug reactions through self-reporting using the Pharmacovigilance Program of India
(PvPI) helpline/app.
• If anyone becomes symptomatic while on prophylaxis he/she should immediately contact the
health facility, get tested as per national guidelines and follow the standard treatment protocol.
• All asymptomatic contacts of laboratory confirmed cases should remain in home quarantine as
per the national guidelines, even if they are on prophylactic therapy.
• Simultaneously, proof of concept and pharmacokinetics studies be taken up expeditiously.
Source:
https://icmr.nic.in/content/covid-19
 
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